A peptide fragment of histone H3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Histone H3K9Me2 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27526

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-N6,N6-dimethyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginine, trifluoroacetate salt
Synonyms
  • Histone H3 (3-17) (Lys9me2)
  • H-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me2)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH
  • [Lys(Me2)9]-Histone H3 (3-17)
  • TKQTAR-K(Me2)-STGGKAPR
Molecular Formula
C67H123N25O21 • XCF3COOH
Formula Weight
1614.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.CN(C)CCCC[C@H](NC([C@@H](NC([C@H](C)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@]([H])(N[H])[C@H](O)C)=O)CCCCN)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@]([H])(C(NCC(NCC(N[C@H](C(N[C@@H](C)C(N1CCC[C@H]1C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O)=O)=O)[C@H](O)C)=O)CO)=O
InChi Code
InChI=1S/C67H123N25O21.C2HF3O2/c1-34(80-63(110)52(38(5)96)90-58(105)43(23-24-47(70)97)85-55(102)41(18-9-12-26-69)86-61(108)50(71)36(3)94)53(100)83-42(20-14-27-76-66(72)73)56(103)84-40(19-10-13-29-91(6)7)57(104)88-45(33-93)59(106)89-51(37(4)95)62(109)79-31-48(98)78-32-49(99)82-39(17-8-11-25-68)54(101)81-35(2)64(111)92-30-16-22-46(92)60(107)87-44(65(112)113)21-15-28-77-67(74)75;3-2(4,5)1(6)7/h34-46,50-52,93-96H,8-33,68-69,71H2,1-7H3,(H2,70,97)(H,78,98)(H,79,109)(H,80,110)(H,81,101)(H,82,99)(H,83,100)(H,84,103)(H,85,102)(H,86,108)(H,87,107)(H,88,104)(H,89,106)(H,90,105)(H,112,113)(H4,72,73,76)(H4,74,75,77);(H,6,7)/t34-,35-,36+,37+,38+,39-,40-,41-,42-,43-,44-,45-,46-,50-,51-,52-;/m0./s1
InChi Key
OAIIXVXRJKPVIT-DIAKBDEHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $224

    Add
    Product Description

    Histone H3K9Me2 (3-17) is a peptide fragment of histone H3 that corresponds to amino acid residues 4-18 of the human histone H3 sequence. Dimethylation of histone H3 at lysine 9 is associated with transcriptional repression.1 Heterochromatin protein 1-α (HP1-α), HP1-β, and HP1-γ selectively bind histone H3 N-terminal peptides containing dimethylated lysine 9 over unmodified lysine 9.2 In mouse embryos, maternal chromatin containing H3K9Me2 is bound by PGC7, which preserves DNA methylation and protects 5-methylcytosine from conversion to 5-hydroxymethylcytosine.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lienert, F., Mohn, F., Tiwari, V.K., et al. Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells. PLoS Genet. 7(6), e1002090 (2011).

    2. Lachner, M., O'Carroll, D., Rea, S., et al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410(6824), 116-120 (2001).

    3. Nakamura, T., Liu, Y.-J., Nakashima, H., et al. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature 486(7403), 415-419 (2012).