A peptide fragment of histone H3
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Histone H3 (5-23) (yeast) (trifluoroacetate salt)

Item No. 27528

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonylglycylglycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine-L-alanyl-L-seryl-L-lysyl, trifluoroacetate salt
Synonyms
  • H3p19
  • QTARKSTGGKAPRKQLASK
Molecular Formula
C84H153N31O26 • XCF3COOH
Formula Weight
2013.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.[H]N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(N[C@@H](CCCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O
InChi Code
InChI=1S/C84H153N31O26.C2HF3O2/c1-42(2)37-56(75(133)100-43(3)67(125)111-57(40-116)76(134)109-55(82(140)141)22-11-15-33-88)110-74(132)54(27-29-61(91)121)107-70(128)50(20-9-13-31-86)105-72(130)53(24-17-35-97-84(94)95)108-78(136)59-25-18-36-115(59)81(139)45(5)102-69(127)49(19-8-12-30-85)103-63(123)39-98-62(122)38-99-79(137)64(46(6)118)114-77(135)58(41-117)112-73(131)51(21-10-14-32-87)106-71(129)52(23-16-34-96-83(92)93)104-66(124)44(4)101-80(138)65(47(7)119)113-68(126)48(89)26-28-60(90)120;3-2(4,5)1(6)7/h42-59,64-65,116-119H,8-41,85-89H2,1-7H3,(H2,90,120)(H2,91,121)(H,98,122)(H,99,137)(H,100,133)(H,101,138)(H,102,127)(H,103,123)(H,104,124)(H,105,130)(H,106,129)(H,107,128)(H,108,136)(H,109,134)(H,110,132)(H,111,125)(H,112,131)(H,113,126)(H,114,135)(H,140,141)(H4,92,93,96)(H4,94,95,97);(H,6,7)/t43-,44-,45-,46+,47+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-,65-;/m0./s1
InChi Key
JEOHGYKKLABXDM-KSIQEHLDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $334

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    Product Description

    Histone H3 (5-23) is a peptide fragment of histone H3 that corresponds to amino acid residues 6-24 of S. cerevisiae histone H3 (Hht1). The yeast histone H3 (5-23) sequence is similar to the human histone H3 (5-23) sequence but contains one amino acid substitution at residue 18 of the peptide. Histone H3 can be acetylated at lysine 14.1 Histone H3 (5-23) has been used as a substrate to measure the activity of various histone acetyltransferases in vitro, including wild-type and mutant versions of yeast ESA1 and Tetrahymena tGCN5, as well as the recombinant MYST domain of human monocytic leukemia zinc finger protein (MOZ).2,3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holbert, M.A., Sikorski, T., Carten, J., et al. The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. The Journal of Biological Chemisty 282(50), 36603-36613 (2007).

    2. Yan, Y., Harper, S., Speicher, D.W., et al. The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nat. Struct. Biol. 9(11), 862-869 (2002).

    3. Mehta, K.R., Chan, Y.M., Lee, M.X., et al. Mutagenesis of tGCN5 core region reveals two critical surface residues F90 and R140. Biochem. Bioph. Res. Commun. 400(3), 363-368 (2010).