A peptide fragment of histone H3
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Histone H3K14Ac (9-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27529

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-seryl-L-threonylglycylglycyl-N6-acetyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutamine, trifluoroacetate salt
Synonyms
  • Histone H3 (9-19) (Lys14ac)
  • H3K14Ac
  • KSTGG-K(Ac)-APRKQ
  • [Lys(Ac)14]-Histone H3 (9-19)
Molecular Formula
C50H90N18O16 • XCF3COOH
Formula Weight
1199.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.CC(NCCCC[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)C)=O)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CCCCN)N[H])=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C50H90N18O16.C2HF3O2/c1-27(48(82)68-23-11-16-36(68)46(80)64-33(15-10-22-58-50(55)56)43(77)63-32(13-5-8-20-52)44(78)65-34(49(83)84)17-18-37(54)72)61-42(76)31(14-6-9-21-57-29(3)71)62-39(74)25-59-38(73)24-60-47(81)40(28(2)70)67-45(79)35(26-69)66-41(75)30(53)12-4-7-19-51;3-2(4,5)1(6)7/h27-28,30-36,40,69-70H,4-26,51-53H2,1-3H3,(H2,54,72)(H,57,71)(H,59,73)(H,60,81)(H,61,76)(H,62,74)(H,63,77)(H,64,80)(H,65,78)(H,66,75)(H,67,79)(H,83,84)(H4,55,56,58);(H,6,7)/t27-,28+,30-,31-,32-,33-,34-,35-,36-,40-;/m0./s1
InChi Key
DZLFYYNYZGXFEY-WAWMZBQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $169

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    Product Description

    Histone H3K14Ac (9-19) is a peptide fragment of histone H3 that corresponds to amino acid residues 10-20 of the human histone H3 sequence. Acetylation of H3K14 is associated with transcriptional activation and is required for trimethylation of H3K4.1,2,3 Histone H3K14Ac (9-19) has been used to elucidate the structure of the Tetrahymena GCN5 histone acetyltransferase (HAT) domain.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gatta, R., and Mantovani, R. Single nucleosome ChIPs identify an extensive switch of acetyl marks on cell cycle promoters. Cell Cycle 9(11), 2149-2159 (2010).

    2. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).

    3. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).

    4. Rojas, J.R., Trievel, R.C., Zhou, J., et al. Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature 401(6748), 93-98 (1999).