A biotinylated peptide fragment of histone H3
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Histone H3K27Me1 (15-39)-K-biotin (trifluoroacetate salt)

Item No. 27530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • [Lys(Me1)27]-Histone H3 (15-39)-K(Biotin)
  • Histone H3 (15-39) (Lys27me1)
  • APRKQLATKAAR-K(Me)-SAPATGGVKKPH-K(Biotin)-NH2
Molecular Formula
C129H226N44O32S • XCF3COOH
Formula Weight
2937.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCNC)C(N[C@@H](CO)C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CCCCNC(CCCC[C@@H]4SC[C@@](N5)([H])[C@]4([H])NC5=O)=O)C(N)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C129H226N44O32S.C2HF3O2/c1-67(2)59-87(163-114(192)85(46-47-95(135)177)158-109(187)80(35-17-23-49-131)156-111(189)84(40-29-55-145-128(139)140)159-119(197)92-42-30-56-171(92)124(202)69(5)134)115(193)151-72(8)106(184)169-101(76(12)176)123(201)161-79(34-16-22-48-130)108(186)150-70(6)104(182)149-71(7)105(183)155-83(39-28-54-144-127(137)138)110(188)157-81(37-20-26-52-141-13)113(191)165-89(64-174)117(195)153-74(10)125(203)172-57-31-41-91(172)118(196)152-73(9)107(185)168-100(75(11)175)121(199)147-62-97(179)146-63-98(180)167-99(68(3)4)122(200)160-82(36-18-24-50-132)112(190)162-86(38-19-25-51-133)126(204)173-58-32-43-93(173)120(198)164-88(60-77-61-142-66-148-77)116(194)154-78(103(136)181)33-21-27-53-143-96(178)45-15-14-44-94-102-90(65-206-94)166-129(205)170-102;3-2(4,5)1(6)7/h61,66-76,78-94,99-102,141,174-176H,14-60,62-65,130-134H2,1-13H3,(H2,135,177)(H2,136,181)(H,142,148)(H,143,178)(H,146,179)(H,147,199)(H,149,182)(H,150,186)(H,151,193)(H,152,196)(H,153,195)(H,154,194)(H,155,183)(H,156,189)(H,157,188)(H,158,187)(H,159,197)(H,160,200)(H,161,201)(H,162,190)(H,163,192)(H,164,198)(H,165,191)(H,167,180)(H,168,185)(H,169,184)(H4,137,138,144)(H4,139,140,145)(H2,166,170,205);(H,6,7)/t69-,70-,71-,72-,73-,74-,75+,76+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,99-,100-,101-,102-;/m0./s1
InChi Key
RTNPEKOPMOQXIH-YQVIXJAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $253

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    Product Description

    Histone H3K27Me1 (15-39) is a peptide fragment of histone H3 that corresponds to amino acid residues 16-40 of the human histone H3.1 and H3.2 sequences. It is monomethylated at lysine 27 and biotinylated via a C-terminal lysine linker. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation.1 Levels of H3K27Me1 are increased in patients with metastatic hormone-naïve and castration-resistant prostate cancer.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferrari, K.J., Scelfo, A., Jammula, S., et al. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol. Cell 53(1), 49-62 (2014).

    2. Ellinger, J., Kahl, P., von der Gathen, J., et al. Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer. Cancer Invest. 30(2), 92-97 (2012).