A biotinylated peptide fragment of histone H3
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Histone H3K36Me2 (21-44)-GK-biotin (trifluoroacetate salt)

Item No. 27531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-N6,N6-dimethyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycylglycyl-L-lysine-biotin, trifluoroacetate salt
Synonyms
  • ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin)
  • [Lys(Me2)36]-Histone H3 (21-44)-GK(Biotin)
  • Histone H3 (21-44) (Lys36me2)-biotin
Molecular Formula
C129H218N44O33S • XCF3COOH
Formula Weight
2945.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.CN(C)CCCC[C@H](NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@H](C)NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)N)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)=O)=O)=O)[C@H](O)C)=O)=O)=O)C(C)C)=O)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@H](C(N5CCC[C@H]5C(NCC(NCC(N[C@H](C(O)=O)CCCCNC(CCCC[C@@H]6SC[C@@]([H])([C@@]6(N7)[H])NC7=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O
InChi Code
InChI=1S/C129H218N44O33S.C2HF3O2/c1-68(2)100(166-99(182)64-146-97(180)62-148-119(198)101(74(8)175)168-107(186)72(6)152-117(196)92-39-28-55-171(92)122(201)73(7)153-115(194)89(65-174)164-112(191)80(31-15-20-48-131)156-109(188)82(35-24-51-142-126(134)135)155-106(185)71(5)150-105(184)70(4)151-108(187)79(30-14-19-47-130)159-121(200)102(75(9)176)167-104(183)69(3)133)120(199)158-81(32-18-23-54-170(10)11)110(189)160-84(33-16-21-49-132)123(202)173-57-29-40-93(173)118(197)163-88(59-77-60-140-67-149-77)114(193)157-83(36-25-52-143-127(136)137)111(190)162-87(58-76-43-45-78(177)46-44-76)113(192)161-85(37-26-53-144-128(138)139)124(203)172-56-27-38-91(172)116(195)147-61-96(179)145-63-98(181)154-86(125(204)205)34-17-22-50-141-95(178)42-13-12-41-94-103-90(66-207-94)165-129(206)169-103;3-2(4,5)1(6)7/h43-46,60,67-75,79-94,100-103,174-177H,12-42,47-59,61-66,130-133H2,1-11H3,(H,140,149)(H,141,178)(H,145,179)(H,146,180)(H,147,195)(H,148,198)(H,150,184)(H,151,187)(H,152,196)(H,153,194)(H,154,181)(H,155,185)(H,156,188)(H,157,193)(H,158,199)(H,159,200)(H,160,189)(H,161,192)(H,162,190)(H,163,197)(H,164,191)(H,166,182)(H,167,183)(H,168,186)(H,204,205)(H4,134,135,142)(H4,136,137,143)(H4,138,139,144)(H2,165,169,206);(H,6,7)/t69-,70-,71-,72-,73-,74+,75+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-;/m0./s1
InChi Key
HQWSCKSKOPJCSY-VUDJXMGVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $262

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    Product Description

    Histone H3K36Me2 (21-44) is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is dimethylated at lysine 36 and biotinylated via a C-terminal GK linker. Dimethylation of H3K36 is enriched at coding regions of genes and correlates with the initiation, but not maintenance, of active transcription.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Jackson, J., Simon, M.D., et al. Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. The Journal of Biological Chemisty 284(12), 7970-7976 (2009).

    2. Rao, B., Shibata, Y., Strahl, B.D., et al. Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Mol. Cell. Biol. 25(21), 9447-9459 (2005).