A biotinylated peptide fragment of histone H3
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Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt)

Item No. 27532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-((S)-2-((S)-2-(2-(2-((2S,3R)-2-((S)-2-((S)-1-(L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl)pyrrolidine-2-carboxamido)propanamido)-3-hydroxybutanamido)acetamido)acetamido)-3-methylbutanamido)-6-(trimethylammonio)hexanoyl)-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycylglycyl-N6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-lysinate, trifluoroacetate salt
Synonyms
  • ATKAARKSAPATGGV-K(Me3)-KPHRYRPG-GK(Biotin)
  • Histone H3 (21-44) (Lys36me3)
  • [Lys(Me3)36]-Histone H3 (21-44)-GK(Biotin)
Molecular Formula
C130H220N44O33S • XCF3COOH
Formula Weight
2959.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.C[N+](C)(C)CCCC[C@H](NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@H](C)NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)N)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)=O)=O)=O)[C@H](O)C)=O)=O)=O)C(C)C)=O)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@H](C(N5CCC[C@H]5C(NCC(NCC(N[C@H](C([O-])=O)CCCCNC(CCCC[C@@H]6SC[C@@]([H])([C@@]6(N7)[H])NC7=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O
InChi Code
InChI=1S/C130H220N44O33S.C2HF3O2/c1-69(2)101(167-100(183)65-147-98(181)63-149-120(199)102(75(8)176)169-108(187)73(6)153-118(197)93-40-29-55-171(93)123(202)74(7)154-116(195)90(66-175)165-113(192)81(32-16-21-49-132)157-110(189)83(36-25-52-143-127(135)136)156-107(186)72(5)151-106(185)71(4)152-109(188)80(31-15-20-48-131)160-122(201)103(76(9)177)168-105(184)70(3)134)121(200)159-82(33-19-24-58-174(10,11)12)111(190)161-85(34-17-22-50-133)124(203)173-57-30-41-94(173)119(198)164-89(60-78-61-141-68-150-78)115(194)158-84(37-26-53-144-128(137)138)112(191)163-88(59-77-44-46-79(178)47-45-77)114(193)162-86(38-27-54-145-129(139)140)125(204)172-56-28-39-92(172)117(196)148-62-97(180)146-64-99(182)155-87(126(205)206)35-18-23-51-142-96(179)43-14-13-42-95-104-91(67-208-95)166-130(207)170-104;3-2(4,5)1(6)7/h44-47,61,68-76,80-95,101-104,175-177H,13-43,48-60,62-67,131-134H2,1-12H3,(H39-,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,205,206,207);(H,6,7)/t70-,71-,72-,73-,74-,75+,76+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,101-,102-,103-,104-;/m0./s1
InChi Key
SSUAUJKNRYZBTM-OYLSTRRTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $253

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    Product Description

    Histone H3K36Me3 (21-44) is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences. It is trimethylated at lysine 36 and biotinylated via a C-terminal GK linker. Trimethylation of H3K36 is increased in the G1 and early S phases of the cell cycle where it binds to and recruits the mismatch recognition protein MutSα in preparation for DNA replication and mismatch repair.1 H3K36 trimethylation is found in greater amounts on exons compared with introns in C. elegans, mouse, and human genome-wide maps of histone H3 tail methylations.2

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    References & Product Citations
    Product Description References

    1. Li, F., Mao, G., Tong, D., et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153(3), 590-600 (2013).

    2. Kolasinska-Zwierz, P., Down, T., Latorre, I., et al. Differential chromatin marking of introns and expressed exons by H3K36me3. Nat. Genet. 41(3), 376-381 (2009).