A phenol with diverse biological activities
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Mulberroside A

Item No. 27545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(1E)-2-[4-(β-D-glucopyranosyloxy)-2-hydroxyphenyl]ethenyl]-5-hydroxyphenyl, β-D-glucopyranoside
CAS Number
102841-42-9
Molecular Formula
C26H32O14
Formula Weight
568.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
216, 301, 324 nm
SMILES
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC(O)=CC(/C=C/C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3O)=C2)O1
InChi Code
InChI=1S/C26H32O14/c27-9-17-19(31)21(33)23(35)25(39-17)37-14-4-3-12(16(30)8-14)2-1-11-5-13(29)7-15(6-11)38-26-24(36)22(34)20(32)18(10-28)40-26/h1-8,17-36H,9-10H2/b2-1+/t17-,18-,19-,20-,21+,22+,23-,24-,25-,26-/m1/s1
InChi Key
HPSWAEGGWLOOKT-VUNDNAJOSA-N
Origin
Plant/Cortex mori
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    Mulberroside A is a phenol and stilbene glucoside form of oxyresveratrol (Item No. 12028) originally isolated from M. alba (mulberry) roots that has diverse biological activities.1,2,3,4 It inhibits pregnane X receptor-mediated P-glycoprotein (P-gp) luciferase reporter activity induced by rifampicin (Item No. 14423) in LS174T cells when used at concentrations ranging from 5 to 20 μM.1 Mulberroside A decreases expression of TNF-α, IL-1β, and IL-6, inhibits caspase-1 activation, and increases cell viability in an isolated rat cortical neuron model of oxygen-glucose deprivation-induced ischemia and reperfusion injury.2 Topical administration of mulberroside A (2 and 5% v/v) reduces UVB-induced hyperpigmentation, levels of the melanogenesis enzymes tyrosinase, tyrosinase-related protein 1 (TRP-1), and microphthalmia-associated transcription factor (MITF), and tyrosinase activity in brown guinea pig skin.3 Mulberroside A (10, 20, and 40 mg/kg) decreases serum levels of uric acid, creatinine, and urea nitrogen, reduces renal vacuolar and granular degeneration, and increases fractional excretion of uric acid and urinary urate excretion in hyperuricemic mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Huang, L., Sun, J., et al. Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells. J. Biochem. Mol. Toxicol. (2016).

    2. Wang, C.-P., Zhang, L.-Z., Li, G.-C., et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J. Neurosci. Res. 92(7), 944-954 (2014).

    3. Park, K.-T., Kim, J.-K., Hwang, D., et al. Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation. Food Chem. Toxicol. 49(12), 3038-3045 (2011).

    4. Wang, C.-P., Wang, Y., Wang, X., et al. Mulberroside A possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 77(8), 786-794 (2011).