A hepatitis C virus NS5A inhibitor
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Pibrentasvir

Item No. 27546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-[[(2R,5R)-1-[3,5-difluoro-4-[4-(4-fluorophenyl)-1-piperidinyl]phenyl]-2,5-pyrrolidinediyl]bis[(6-fluoro-1H-benzimidazole-5,2-diyl)-(2S)-2,1-pyrrolidinediyl[(1S)-1-[(1R)-1-methoxyethyl]-2-oxo-2,1-ethanediyl]]]bis-carbamic acid, dimethyl ester
CAS Number
1353900-92-1
Molecular Formula
C57H65F5N10O8
Formula Weight
1113.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
252, 284 nm
SMILES
FC1=C(N2CCC(C3=CC=C(F)C=C3)CC2)C(F)=CC(N4[C@@H](C5=C(F)C=C(NC([C@@H]6CCCN6C([C@H]([C@H](OC)C)NC(OC)=O)=O)=N7)C7=C5)CC[C@@H]4C8=CC(N=C([C@H]9N(C([C@H]([C@H](OC)C)NC(OC)=O)=O)CCC9)N%10)=C%10C=C8F)=C1
InChi Code
InChI=1S/C57H65F5N10O8/c1-29(77-3)49(67-56(75)79-5)54(73)70-19-7-9-47(70)52-63-41-25-35(37(59)27-43(41)65-52)45-15-16-46(72(45)34-23-39(61)51(40(62)24-34)69-21-17-32(18-22-69)31-11-13-33(58)14-12-31)36-26-42-44(28-38(36)60)66-53(64-42)48-10-8-20-71(48)55(74)50(30(2)78-4)68-57(76)80-6/h11-14,23-30,32,45-50H,7-10,15-22H2,1-6H3,(H,63,65)(H,64,66)(H,67,75)(H,68,76)/t29-,30-,45-,46-,47+,48+,49+,50+/m1/s1
InChi Key
VJYSBPDEJWLKKJ-NLIMODCCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $42

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    50 mg

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    Cayman Chemical
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    Product Description

    Pibrentasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A).1 It inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1-6 (EC50s = 1.4-4.3 pM). Pibrentasvir acts synergistically with the HCV NS3/4A protease inhibitor glecaprevir to inhibit HCV genotype 1b-Con1 replication in replicon cells.2 Formulations containing pibrentasvir have been used in combination with glecaprevir in the treatment of HCV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wagner, R.R., Randolph, J.T., Patel, S.V., et al. Highlights of the structure-activity relationships of benzimidazole linked pyrrolidines leading to the discovery of the hepatitis C virus NS5A inhibitor pibrentasvir (ABT-530). J. Med. Chem. 61(9), 4052-4066 (2018).

    2. Ng, T.I., Krishnan, P., Pilot-Matias, T., et al. In vitro antiviral activity and resistance profile of the next-generation hepatitis C virus NS5A inhibitor pibrentasvir. Antimicrob. Agents Chemother. 61(5), e02558-02516 (2017).