3,4-Dihydroxybenzaldehyde

3,4-Dihydroxybenzaldehyde is a polyphenol that has been found in S. miltiorrhiza and has diverse biological activities, including antibacterial, antioxidative, and anticancer properties.^1,2,3,4 It is active against methicillin-resistant S. aureus (MRSA) when used at a concentration of 0.01 µg/ml.² It prevents hexavalent chromium-induced formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in a concentration-dependent manner and increases glutathione (GSH) levels in isolated human erythrocytes.¹ 3,4-Dihydroxybenzaldehyde selectively inhibits human DNA topoisomerase II (IC₅₀ = 150 µM) over human topoisomerase I and a variety of mammalian polymerases (IC₅₀s = >200 µM).³ It inhibits proliferation of HT-29 cells when used at a concentration of 362 µM but not HCT116 cells at a concentration of 100 µM.^4,3

WARNING This product is not for human or veterinary use.

1. Husain, N., and Mahmood, R. 3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity. Toxicol. In Vitro 50, 293-304 (2018).

2. Rempe, C.S., Burris, K.P., Woo, H.L., et al. Computational ranking of yerba mate small molecules based on their predicted contribution to antibacterial activity against methicillin-resistant Staphylococcus aureus. PLoS One 10(5), e0123925 (2015).

3. Kuriyama, I., Nakajima, Y., Nishida, H., et al. Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Mol. Med. Rep. 8(2), 535-542 (2013).

4. Zhong, S., Li, Y.-G., Ji, D.-F., et al. Protocatechualdehyde induces S-phase arrest and apoptosis by stimulating the p27KIP1-Cyclin A/D₁-CDK2 and mitochondrial apoptotic pathways in HT-29 cells. Molecules 21(7), 934 (2016).