Obovatol

Obovatol is a lignan polyphenol that has been found in M. officinalis and has diverse biological activities.^1,2,3 It inhibits epinephrine- or arachidonate-induced aggregation of isolated rat platelets (IC₅₀s = 59 and 54 µM, respectively).¹ Obovatol (50 µM) induces cell cycle arrest at the S phase and apoptosis in SW620 colorectal cancer cells.² It reduces tumor volume and weight in a SW620 mouse xenograft model when administered at a dose of 6 mg/kg per day. Obovatol (1 mg/kg per day for three months) decreases hippocampal and cortical amyloid-β (Aβ) 1-42 (Aβ42) fibril formation and reduces latency and distance to escape in the Morris water maze in a Tg2576 mouse model of Alzheimer's disease.³

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1. Pyo, M.K., Lee, Y., and Yun-Choi, H.S. Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch. Pharm. Res. 25(3), 325-328 (2002).

2. Lee, S.-K., Kim, H.-N., Kang, Y.-R., et al. Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis. Bioorg. Med. Chem. 16(18), 8397-8402 (2008).

3. Choi, D.-Y., Lee, J.W., Peng, J., et al. Obovatol improves cognitive functions in animal models for Alzheimer’s disease. J. Neurochem. 120(6), 1048-1059 (2012).