A fungal metabolite
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Chrodrimanin B

Item No. 27585

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2R,7aR,8S,9aR,13aS,13bS)-1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-2H,4H-benzo[a]pyrano[3,4-j]xanthene-4,11(7aH)-dione
CAS Number
132196-54-4
Synonyms
  • Thailandolide B
Molecular Formula
C27H32O8
Formula Weight
484.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: 1 mg/mlMethanol: Soluble
SMILES
O=C(C)O[C@H]1[C@@H](C)OC(C2=C1C3=C(C=C2O)O[C@@]([C@@]4([H])C3)(C)[C@@H](O)C[C@@]([C@]4(C)C=C5)([H])C(C)(C)C5=O)=O
InChi Code
InChI=1S/C27H32O8/c1-12-23(34-13(2)28)21-14-9-18-26(5)8-7-19(30)25(3,4)17(26)11-20(31)27(18,6)35-16(14)10-15(29)22(21)24(32)33-12/h7-8,10,12,17-18,20,23,29,31H,9,11H2,1-6H3/t12-,17+,18+,20+,23+,26+,27-/m1/s1
InChi Key
DYQKBALSPZQWQD-FWEFFTEASA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Chrodrimanin B is a meroterpenoid fungal metabolite that has been found in Talaromyces species.1 It has insecticidal activity against third instar silkworm larvae (LD50 = 10 μg/g of diet). Chrodrimanin B selectively inhibits the silkworm GABA receptor RDL (IC50 = 1.13 nM) over human α1β2γ2 subunit-containing GABA receptors (IC50 = 1.48 μM).2 The structure of thailandolide B, originally described as a C-9 epimer of chrodrimanin B, was revised in 2012 and is identical to that of chrodrimanin B.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hayashi, H., Oka, Y., Kai, K., et al. A new meroterpenoid, chrodrimanin C, from YO-2 of Talaromyces sp. Biosci. Biotech. Biochem. 76(4), 745-748 (2012).

    2. Xu, Y., Furutani, S., Ihara, M., et al. Meroterpenoid chrodrimanins are selective and potent blockers of insect GABA-gated chloride channels. PLoS One 10(4), e0122629 (2015).