A potent inhibitor of γ-secretase
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MRK-560

Item No. 27599

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide
CAS Number
677772-84-8
Molecular Formula
C19H17ClF5NO4S2
Formula Weight
517.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 50 mM
SMILES
O=S(N[C@H]1CC[C@](S(C2=CC=C(Cl)C=C2)(=O)=O)(C3=C(F)C=CC(F)=C3)CC1)(C(F)(F)F)=O
InChi Code
InChI=1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+
InChi Key
WDZVWDXOIGQJIO-UJKQEGAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $117

    Add

    5 mg

    $400

    Add
    Product Description

    MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM).1 In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively).2 It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer's disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Churcher, I., Beher, D., Best, J.D., et al. 4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors. Bioorg. Med. Chem. Lett. 16(2), 280-284 (2006).

    2. Best, J.D., Jay, M.T., Otu, F., et al. In vivo characterization of Aβ(40) changes in brain and cerebrospinal fluid using the novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat. J. Pharmacol. Exp. Ther. 317(2), 786-790 (2006).

    3. Townsend, M., Qu, Y., Gray, A., et al. Oral treatment with a γ-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer’s disease. J. Pharmacol. Exp. Ther. 333(1), 110-119 (2010).