A phenol with diverse biological activities
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Isomer(s)
365332-Methoxy-4-methylphenol
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Tyrosol

Item No. 27600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-benzeneethanol
CAS Number
501-94-0
Synonyms
  • NSC 59876
  • p-HPEA
Molecular Formula
C8H10O2
Formula Weight
138.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
225, 279 nm
SMILES
OC1=CC=C(CCO)C=C1
InChi Code
InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2
InChi Key
YCCILVSKPBXVIP-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 g

    $103

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    250 g

    $203

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    500 g

    $303

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    Product Description

    Tyrosol is a phenol that has been found in olives and olive oil and has diverse biological activities.1,2,3,4 It is fungicidal against H. capsulatum and C. posadasii with minimum fungicidal concentration (MFC) values of 170-710 and 1,420 μg/ml, respectively.1 Tyrosol (70-280 mg/kg) increases survival and pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury.2 It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU).3 Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brilhante, R.S., Caetano, É.P., Lima, R.A., et al. Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi. Braz. J. Microbiol. 47(4), 917-924 (2016).

    2. Wang, W.C., Xia, Y.M., Yang, B., et al. Protective effects of tyrosol against LPS-induced acute lung injury via inhibiting NF-κB and AP-1 activation and activating the HO-1/Nrf2 pathways. Biol. Pharm. Bull. 40(5), 583-593 (2017).

    3. Sato, K., Mihara, Y., Kanai, K., et al. Tyrosol ameliorates lipopolysaccharide-induced ocular inflammation in rats via inhibition of nuclear factor (NF)-κB activation. J. Vet. Med. Sci. 78(9), 1429-1438 (2016).

    4. Plotnikov, M.B., Aliev, O.I., Sidekhmenova, A.V., et al. Effect of p-tyrosol on hemorheological parameters and cerebral capillary network in young spontaneously hypertensive rats. Microvasc. Res. 119, 91-97 (2018).