A phenothiazine with diverse biological activities
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Triflupromazine (hydrochloride)

Item No. 27610

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine, monohydrochloride
CAS Number
1098-60-8
Synonyms
  • Siquil
Molecular Formula
C18H19F3N2S • HCl
Formula Weight
388.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: 5 mg/mlEthanol:PBS (pH 7.2) (1:10): 0.09 mg/ml
λmax
259, 308 nm
SMILES
FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1.Cl
InChi Code
InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChi Key
FTNWXGFYRHWUKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $36

    Add

    5 g

    $128

    Add

    10 g

    $236

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Triflupromazine is a phenothiazine with diverse biological activities.1,2,3,4 It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).1 Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).2 It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.3 Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.4 Formulations containing triflupromazine were previously used as antipsychotics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Snyder, S.H., Greenberg, D., and Yamumura, H.I. Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects. J. Psychiatr. Res. 11, 91-95 (1974).

    2. Tuomisto, J. A new modification for studying 5-HT uptake by blood platelets: A re-evaluation of tricyclic antidepressants as uptake inhibitors. J. Pharm. Pharmacol. 26(2), 92-100 (1974).

    3. De Castro, S.L., Soeiro, M.N., and De Meirelles Mde, N. Trypanosoma cruzi: Effect of phenothiazines on the parasite and its interaction with host cells. Mem. Inst. Oswaldo Cruz 87(2), 209-215 (1992).

    4. Dastidar, S.G., Debnath, S., Mazumdar, K., et al. Triflupromazine: A microbicide non-antibiotic compound. Acta Microbiol. Immuno. Hung. 51(1-2), 75-83 (2004).