Collismycin A

Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties.¹ It is active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC₅₀s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC₅₀ = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC₅₀ = >100 µM).^2,3 Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.³ Collismycin A (1 µM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid (Item No. 11017).²

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1. Gomi, S., Amano, S., Sato, E., et al. Novel antibiotics SF2738A, B and C, and their analogs produced by Streptomyces sp. J. Antibiot. (Tokyo) 47(12), 1385-1394 (1994).

2. Garcia, I., Vior, N.M., González-Sabín, J., et al. Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity. Chem. Biol. 20(8), 1022-1032 (2013).

3. Kawatani, M., Muroi, M., Wada, A., et al. Proteomic profiling reveals that collismycin A is an iron chelator. Sci. Rep. 6:38385, (2016).