A small molecule inhibitor of replication protein A
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HAMNO

Item No. 27631

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[(2-hydroxyphenyl)amino]methylene]-2(1H)-naphthalenone
CAS Number
138736-73-9
Molecular Formula
C17H13NO2
Formula Weight
263.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.25 mg/ml
λmax
211, 235, 263, 321, 448, 472 nm
SMILES
O=C1/C(C2=CC=CC=C2C=C1)=C\NC3=C(O)C=CC=C3
InChi Code
InChI=1S/C17H13NO2/c19-16-10-9-12-5-1-2-6-13(12)14(16)11-18-15-7-3-4-8-17(15)20/h1-11,18,20H/b14-11-
InChi Key
NADCEWZYITXLKJ-KAMYIIQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    25 mg

    $462

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    Cayman Chemical
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    Product Description

    HAMNO is a small molecule inhibitor of replication protein A (RPA).1 It selectively binds to and inhibits DNA binding domain F (DBD-F) on RPA70 when used at concentrations up to 100 µM. HAMNO inhibits etoposide-induced autophosphorylation of ATR kinase and subsequent phosphorylation of RPA32 in UMSCC38 cells when used at concentrations of 10 and 20 µM. HAMNO (1 mg/kg), in combination with etoposide (Item No. 12092), reduces tumor growth in UMSCC11B and UMSCC38 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Glanzer, J.G., Liu, S., Wang, L., et al. RPA inhibition increases replication stress and suppresses tumor growth. Cancer Res. 74(18), 5165-5172 (2014).