An activator of K2P2.1/TREK1 and K2P10.1/TREK2
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Product Categories

Product Type

Small Molecule Modulators
Ion Channel Modulators
Activators

Research Area

ML-335

Item No. 27635

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-benzamide
CAS Number
825658-06-8
Molecular Formula
C15H14Cl2N2O3S
Formula Weight
373.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.04 mg/mlEthanol: 5 mg/ml
λmax
258 nm
SMILES
CS(NC1=CC=C(C(NCC2=C(Cl)C=C(Cl)C=C2)=O)C=C1)(=O)=O
InChi Code
InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20)
InChi Key
RDFIQTZRJRVFHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $280

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    50 mg

    $525

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    Product Description

    ML-335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 µM, respectively, in Xenopus oocytes).1 It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML-335 activates K2P2.1/TREK1 by binding to the C-type gate, which is the active site of TREK channels.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lolicato, M., Arrigoni, C., Mori, T., et al. K2P2.1(TREK-1): Activator complexes reveal a cryptic selectivity filter binding site. Nature 547(7663), 364-368 (2017).