An inhibitor of amyloid-β aggregation
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DWK-1339

Item No. 27642

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-benzofuran
CAS Number
1018946-38-7
Synonyms
  • MDR-1339
Molecular Formula
C20H22O4
Formula Weight
326.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMSO: 30mg/mLEthanol: 2mg/mL
λmax
214, 315, 329 nm
SMILES
COCCCC1=CC=C2C(C=C(C3=CC(OC)=C(OC)C=C3)O2)=C1
InChi Code
InChI=1S/C20H22O4/c1-21-10-4-5-14-6-8-17-16(11-14)13-19(24-17)15-7-9-18(22-2)20(12-15)23-3/h6-9,11-13H,4-5,10H2,1-3H3
InChi Key
CUEPJIGXQLIOIK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $795

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    Product Description

    DWK-1339 is an inhibitor of amyloid-β (Aβ) aggregation.1 It inhibits aggregation of monomeric Aβ (1-42) (Aβ42) and induces disaggregation of Aβ42 fibrils in vitro when used at concentrations ranging from 3.1 to 50 µM. DWK-1339 (10 µM) reduces Aβ42-induced toxicity in HT-22 cells. In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Aβ42-induced acute Alzheimer's disease. It also decreases brain levels of Aβ42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ha, H., Kang, D.W., Kim, H.-M., et al. Discovery of an orally bioavailable benzofuran analogue that serves as a β-amyloid aggregation inhibitor for the potential treatment of Alzheimer’s disease. J. Med. Chem. 61(1), 396-402 (2018).