A selective inhibitor of COX-2
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Lumiracoxib

Item No. 27645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-benzeneacetic acid
CAS Number
220991-20-8
Synonyms
  • COX 189
Molecular Formula
C15H13ClFNO2
Formula Weight
293.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
274 nm
SMILES
CC1=CC(CC(O)=O)=C(NC2=C(Cl)C=CC=C2F)C=C1
InChi Code
InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)
InChi Key
KHPKQFYUPIUARC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    50 mg

    $95

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    100 mg

    $169

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    Product Description

    Lumiracoxib is a selective inhibitor of COX-2 with IC50 values of 0.13 and 67 µM for COX-2 and COX-1, respectively, in isolated human whole blood.1 It reduces increases in the levels of prostaglandin E2 (PGE2; Item No. 14010) induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 1 to 100 µM.1,2 Lumiracoxib (3 and 10 mg/kg) also decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation.3 It reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis when administered at a dose of 2 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Esser, R., Berry, C., Du, Z., et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br. J. Pharmacol. 144(4), 538-550 (2005).

    2. Niederberger, E., Manderscheid, C., and Geisslinger, G. Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib. Biochem. Biophys. Res. Commun. 342(3), 940-948 (2006).

    3. Esser, R.E., Miserendino-Molteni, R., Sharr, M., et al. Pharmacodynamic behaviour of the selective cyclooxygenase-2 inhibitor lumiracoxib in the lipopolysaccharide-stimulated rat air pouch model. Eur. J. Pharm. Sci. 25(1), 25-30 (2005).