An alkaloid with diverse biological activities
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Corydaline

Item No. 27654

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,8,13S,13aR-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine
CAS Number
518-69-4
Synonyms
  • (+)-Corydaline
  • D-Corydaline
  • NSC 406036
Molecular Formula
C22H27NO4
Formula Weight
369.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mlDMSO: 5mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/mlEthanol: Slight soluble
SMILES
COC1=CC=C2C(CN(CCC3=CC(OC)=C(OC)C=C34)[C@]4([H])[C@H]2C)=C1OC
InChi Code
InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1
InChi Key
VRSRXLJTYQVOHC-YEJXKQKISA-N
Origin
Plant/Corydalis yanhusuo
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Corydaline is an alkaloid that has been found in C. cava and has diverse biological activities.1,2,3,4 It inhibits acetylcholinesterase (AChE; IC50 = 15 μM).1 Corydaline is nematocidal against S. ratti and S. venezuelensis third instar larvae with 50% paralysis (PC50) values of 18 and 30 μM, respectively.2 It inhibits thrombin-induced platelet aggregation in vitro (IC50 = 54.16 μg/ml).3 Corydaline (1 and 3 mg/kg) increases gastric emptying in rat models of apomorphine- and laparotomy-induced delayed gastric emptying.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adsersen, A., Kjølbye, A., Dall, O., et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. J. Ethnopharmacol. 113(1), 179-182 (2007).

    2. Satou, T., Koga, M., Matsuhashi, R., et al. Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis. Vet. Parasitol. 104(2), 131-138 (2002).

    3. Zhang, Q., Chen, C., Wang, F.-Q., et al. Simultaneous screening and analysis of antiplatelet aggregation active alkaloids from Rhizoma Corydalis. Pharm. Biol. 54(12), 3113-3120 (2016).

    4. Lee, T.H., Son, M., and Kim, S.Y. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol. Pharm. Bull. 33(6), 958-962 (2010).