Columbianadin

Columbianadin is a coumarin that has been found in A. pubescens and has diverse biological activities.^1,2,3,4 It inhibits depolarization-induced calcium uptake in GH3 rat pituitary cells.¹ Columbianadin inhibits HIV-1 replication in H9 cells (EC₅₀ = 4.6 µM).² It inhibits IL-1β-induced production of IL-6 in A549 cells and reduces inducible nitric oxide synthase (iNOS) levels and LPS-induced NO production in MH-S cells.³ Columbianadin (20-60 mg/kg) decreases the number of alveolar and interstitial macrophages and alveolar wall thickness in a mouse model of LPS-induced lung inflammation. It also reduces formalin-induced paw licking in mice when administered at a dose of 10 mg/kg.⁴

WARNING This product is not for human or veterinary use.

1. Törnquist, K., and Vuorela, H. The furanocoumarin columbianadin inhibits depolarization induced Ca²⁺ uptake in rat pituitary GH3 cells. Planta Med. 56(1), 127-129 (1990).

2. Lee, T.T.-Y., Kashiwada, Y., Huang, L., et al. Suksdorfin: An anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides. Bioorg. Med. Chem. 2(10), 1051-1056 (1994).

3. Lim, H.J., Lee, J.H., Choi, J.S., et al. Inhibition of airway inflammation by the roots of Angelica decursiva and its constituent, columbianadin. J. Ethnopharmacol. 155(2), 1353-1361 (2014).

4. Chen, Y.-F., Tsai, H.-Y., and Wu, T.-S. Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med. 61(1), 2-8 (1995).