A topical anesthetic with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Dyclonine (hydrochloride)

Item No. 27667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride
CAS Number
536-43-6
Synonyms
  • Dyclone
  • Dyclothane
  • Tanaclone
Molecular Formula
C18H27NO2 • HCl
Formula Weight
325.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
221, 279 nm
SMILES
O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl
InChi Code
InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
InChi Key
KNZADIMHVBBPOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 g

    $69

    Add

    10 g

    $106

    Add

    25 g

    $149

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Dyclonine is a topical anesthetic that also has antimicrobial, anticancer, and neuroprotective properties.1,2,3 It is active against S. aureus, B. subtilis, E. coli, P. vulgaris, P. aeruginosa, C. albicans, M. lanosum, and T. mentagrophytes with minimum microbicidal concentrations (MMCs) ranging from 0.006 to 0.8% v/v.1 Dyclonine (25-100 μM) reduces aldehyde dehydrogenase (ALDH) activity in and viability of HSC-4 oral squamous cell carcinoma cells and enhances HSC-4 and OSC19 cell death induced by sulfasalazine (Item No. 15025).2 In vivo, dyclonine (5 mg/kg per day) reduces tumor volume in an HSC-2 mouse xenograft model when administered alone or in combination with sulfasalazine. Dyclonine also induces cerebral frataxin (FXN) production and decreases time to cross and the number of foot slips in a level beam test in a mouse model of Friedreich's ataxia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Florestano, H.J., and Bahler, M.E. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J. Am. Pharm. Assoc. 45(5), 320-325 (1956).

    2. Okazaki, S., Shintani, S., Hirata, Y., et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget 9(73), 33832-33843 (2018).

    3. Sahdeo, S., Scott, B.D., McMackin, M.Z., et al. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich’s ataxia. Hum. Mol. Genet. 23(25), 6848-6862 (2014).