A 5-HT2C receptor agonist
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ORG 12962 (hydrochloride)

Item No. 27675

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine, monohydrochloride
CAS Number
210821-63-9
Synonyms
  • Ro 44-6956
Molecular Formula
C10H11ClF3N3 • HCl
Formula Weight
302.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 50 mM
SMILES
ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl
InChi Code
InChI=1S/C10H11ClF3N3.ClH/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17;/h1-2,15H,3-6H2;1H
InChi Key
FVDILXYXZAAJOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $182

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    25 mg

    $418

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    50 mg

    $774

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    Product Description

    ORG 12962 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C with an EC50 value of 97.72 nM in a FLIPR-based intracellular calcium assay using CHO-K1 cells expressing the human receptor.1 It is selective for 5-HT2C over 5-HT2A and 5-HT2B receptors (EC50s = 419.87 and 524.81 nM, respectively). ORG 12962 (1 and 3.2 mg/kg) has anti-aversive effects in a rat model of panic anxiety induced by dorsolateral periaqueductal gray matter (dPAG) stimulation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, R.H.P., Benwell, K.R., Lamb, H., et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br. J. Pharmacol. 128(1), 13-20 (1999).

    2. Jenck, F., Moreau, J.-L., Berendsen, H.H.G., et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur. Neuropsychopharmacol. 8(3), 161-168 (1998).