A T-type calcium channel inhibitor
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Z944

Item No. 27679

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
CAS Number
1199236-64-0
Molecular Formula
C19H27ClFN3O2
Formula Weight
383.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=C(C1=CC(Cl)=CC(F)=C1)NCC2CCN(CC(NC(C)(C)C)=O)CC2
InChi Code
InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)
InChi Key
JOCLITFYIMJMNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $629

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    Product Description

    Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 µM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3).1 It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 µM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 µM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tringham, E.W., Powell, K.L., Cain, S.M., et al. T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci. Transl Med. 4(121), 121ra119 (2012).

    2. Casillas-Espinosa, P.M., Hicks, A., Jeffreys, A.B., et al. Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One 10(8), e0130012 (2015).