A nucleoside analog with anticancer activity
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Product Categories

Product Type

Biochemicals
Nucleotides/Nucleosides

Research Area

Cancer
Cell Death

Ethynylcytidine

Item No. 27681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3′-C-ethynyl-cytidine
CAS Number
180300-43-0
Synonyms
  • ECyD
  • 1-(3-C-Ethynyl-β-D-ribofuranosyl)cytosine
  • TAS-106
Molecular Formula
C11H13N3O5
Formula Weight
267.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLPBS (pH 7.2): 10mg/mL
λmax
240, 273 nm
SMILES
O[C@H]1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@]1(O)C#C
InChi Code
InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1
InChi Key
JFIWEPHGRUDAJN-DYUFWOLASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.1,2 It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).1 ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimamoto, Y., Fujioka, A., Kazuno, H., et al. Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine. Jpn. J. Cancer Res. 92(3), 343-351 (2001).

    2. Takatori, S., Kanda, H., Takenaka, K., et al. Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil. Cancer Chemother. Pharmacol. 44(2), 97-104 (1999).