A renin inhibitor
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VTP-27999 (trifluoroacetate salt)

Item No. 27689

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-carbamic acid, methyl ester, trifluoroacetate salt
CAS Number
1013937-63-7
Molecular Formula
C26H41ClN4O5 • CF3COOH
Formula Weight
639.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
SMILES
O=C(N1C[C@@]([C@@H](OCCNC(OC)=O)C2=CC(Cl)=CC=C2)([H])CCC1)NC[C@@H](NC)C[C@H]3CCCOC3.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C26H41ClN4O5.C2HF3O2/c1-28-23(14-19-6-5-12-35-18-19)16-30-25(32)31-11-4-8-21(17-31)24(20-7-3-9-22(27)15-20)36-13-10-29-26(33)34-2;3-2(4,5)1(6)7/h3,7,9,15,19,21,23-24,28H,4-6,8,10-14,16-18H2,1-2H3,(H,29,33)(H,30,32);(H,6,7)/t19-,21-,23+,24+;/m1./s1
InChi Key
SYWYSVAEGXHOJO-VIEYARBJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $38

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    5 mg

    $129

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    10 mg

    $218

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    25 mg

    $454

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    Product Description

    VTP-27999 is a renin inhibitor (IC50 = 0.47 nM for the recombinant human enzyme).1 It is selective for renin over the aspartyl proteases β-secretase, cathepsin D, and cathepsin E at 10 µM and is greater than 1,000-fold selective for renin over a panel of more than 250 receptors, ion channels, and enzymes. VTP-27999 (10 mg/kg, p.o.) reduces mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jia, L., Simpson, R.D., Yuan, J., et al. Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med. Chem. Lett. 2(10), 747-751 (2011).