A long-chain saturated acyl CoA
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Alternative(s)
45165Palmitoyl-Coenzyme A (lithium salt)
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Palmitoyl-Coenzyme A (sodium salt)

Item No. 27703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-hexadecanoate, coenzyme A
Synonyms
  • Hexadecanoyl-CoA
  • Palmitoyl-CoA
Molecular Formula
C37H66N7O17P3S • XNa
Formula Weight
1005.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCCCCCCCCCC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
InChi Code
InChI=1S/C37H66N7O17P3S.Na/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44;/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52);/t26-,30-,31-,32+,36-;/m1./s1
InChi Key
QLDJUBHRXUIANF-NNGKVBCISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $283

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    10 mg

    $479

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    25 mg

    $1,087

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    Product Description

    Palmitoyl-coenzyme A (palmitoyl-CoA) is a derivative of CoA (Item Nos. 16147 | 21499) that contains the saturated fatty acid palmitic acid (Item Nos. 10006627 | 43561). It is a substrate for palmitoyltransferases during palmitoylation, a process that adds a palmitoyl group to proteins to anchor them to the membrane or target them to lipid rafts.1 It is also a substrate in the de novo synthesis of sphingolipids.2,3 Palmitoyl-CoA binds to acyl-CoA-binding protein (ACBP; Kd = 0.45 pM) and undergoes β-oxidation in mitochondria.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guan, X., and Fierke, C.A. Understanding protein palmitoylation: Biological significance and enzymology. Sci. China Chem. 54(12), 1888-1897 (2011).

    2. Weiss, B., and Stoffel, W. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249(1), 239-247 (1997).

    3. Lai, M.K.P., Chew, W.S., Torta, F., et al. Biological effects of naturally occurring sphingolipids, uncommon variants, and their analogs. Neuromolecular Med. 18(3), 396-414 (2016).

    4. Rasmussen, J.T., Faergeman, N.J., Kristiansen, K., et al. Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for β-oxidation and glycerolipid synthesis. Biochem. J. 299(Pt 1), 165-170 (1994).