A synthetic derivative of tuftsin
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Selank (acetate)

Item No. 27720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline, monoacetate
CAS Number
2703745-90-6
Molecular Formula
C33H57N11O9 • C2H4O2
Formula Weight
811.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H]1CCCN1C(CNC([C@@H]2CCCN2C([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@H]([C@H](O)C)N)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)O.OC(C)=O
InChi Code
InChI=1S/C33H57N11O9.C2H4O2/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53;1-2(3)4/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38);1H3,(H,3,4)/t19-,20+,21+,22+,23+,24+,26+;/m1./s1
InChi Key
OLIPZUSDWNRQRQ-BPKVXTLESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $169

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    5 mg

    $629

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    10 mg

    $1,086

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    Product Description

    Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities.1,2,3,4 It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM.1 It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test.2 It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine (Item No. 16094) in mice.3 It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Povarov, I.S., Kondratenko, R.V., Derevyagin, V.I., et al. Effect of Selank on spontaneous synaptic activity of rat hippocampal CA1 neurons. Bull. Exp. Biol. Med. 162(5), 640-642 (2017).

    2. Kozlovskaya, M.M., Kozlovskii, I.I., Val'dman, E.A., et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci. Behav. Physiol. 33(9), 853-860 (2003).

    3. Meshavkin, K.V., Kost, N.V., Sokolov, O.Y., et al. Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system. Bull. Exp. Biol. Med. 142(5), 598-600 (2006).

    4. Kolomin, T., Morozova, M., Volkova, A., et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol. Immunol. 58(1), 50-55 (2014).