A diterpene alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Talatisamine

Item No. 27721

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-ethyl-1α,16β-dimethoxy-4-(methoxymethyl)-aconitane-8,14α-diol
CAS Number
20501-56-8
Molecular Formula
C24H39NO5
Formula Weight
421.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1mg/mLDMSO: 2 mg/mLEthanol: 10mg/mL
SMILES
[H][C@]1(C2)C([C@@H](OC)CC[C@]34COC)(C5N(CC)C4)[C@]3([H])CC5[C@]6(O)[C@@]1([H])[C@@H](O)[C@@]2([H])[C@@H](OC)C6
InChi Code
InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3/t13-,14-,15?,16+,17-,18+,19-,20+,21?,22+,23+,24?/m1/s1
InChi Key
BDCURAWBZJMFIK-FIIQKEKKSA-N
Origin
Plant/Aconitum tenuifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $129

    Add

    10 mg

    $218

    Add

    25 mg

    $445

    Add

    50 mg

    $763

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities.1,2,3,4,5 It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 μM).3 Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-β (1-40) (Aβ40; Item No. 21617).4 It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM).2 Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konovalova, R.A., and Orekhov, A.P. Aconite alkaloids. I. Alkaloids of aconitum talassicum. B. Soc. Chim. Fr. 7, 95-105 (1940).

    2. Dzhakhangirov, F.N., Tursunkhodzhaeva, F.M., Sultankhodzhaev, M.N., et al. Spasmolytic activity of diterpenoid alkaloids and their derivatives. Structure-activity relationship. Chem. Nat. Compd. 49(4), 702-706 (2013).

    3. Song, M.K., Liu, H., Jiang, H.L., et al. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons. Neuroscience 155(2), 469-475 (2008).

    4. Wang, Y., Song, M., Hou, L., et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci. Lett. 518(2), 122-127 (2012).

    5. Liu, Z.L., Cao, J., Zhang, H.M., et al. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. J. Agric. Food Chem. 59(8), 3701-3706 (2011).