A diterpene alkaloid with diverse biological activities
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Talatisamine

Item No. 27721

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-ethyl-1α,16β-dimethoxy-4-(methoxymethyl)-aconitane-8,14α-diol
CAS Number
20501-56-8
Molecular Formula
C24H39NO5
Formula Weight
421.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1mg/mLDMSO: 2 mg/mLEthanol: 10mg/mL
SMILES
[H][C@]1(C2)C([C@@H](OC)CC[C@]34COC)(C5N(CC)C4)[C@]3([H])CC5[C@]6(O)[C@@]1([H])[C@@H](O)[C@@]2([H])[C@@H](OC)C6
InChi Code
InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3/t13-,14-,15?,16+,17-,18+,19-,20+,21?,22+,23+,24?/m1/s1
InChi Key
BDCURAWBZJMFIK-FIIQKEKKSA-N
Origin
Plant/Aconitum tenuifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $129

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    10 mg

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    25 mg

    $445

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    50 mg

    $763

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    Product Description

    Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities.1,2,3,4,5 It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 μM).3 Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-β (1-40) (Aβ40; Item No. 21617).4 It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM).2 Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konovalova, R.A., and Orekhov, A.P. Aconite alkaloids. I. Alkaloids of aconitum talassicum. B. Soc. Chim. Fr. 7, 95-105 (1940).

    2. Dzhakhangirov, F.N., Tursunkhodzhaeva, F.M., Sultankhodzhaev, M.N., et al. Spasmolytic activity of diterpenoid alkaloids and their derivatives. Structure-activity relationship. Chem. Nat. Compd. 49(4), 702-706 (2013).

    3. Song, M.K., Liu, H., Jiang, H.L., et al. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons. Neuroscience 155(2), 469-475 (2008).

    4. Wang, Y., Song, M., Hou, L., et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci. Lett. 518(2), 122-127 (2012).

    5. Liu, Z.L., Cao, J., Zhang, H.M., et al. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. J. Agric. Food Chem. 59(8), 3701-3706 (2011).