A trichothecene fungal metabolite
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Harzianum A

Item No. 27740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4β)-4-[hydrogen (2Z,4E,6E)-2,4,6-octatrienedioate]12,13-epoxy-trichothec-9-en-4-ol
CAS Number
156250-74-7
Molecular Formula
C23H28O6
Formula Weight
400.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC1=C[C@]2([H])[C@](C3(C)C4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C=C\C(O)=O)=O)([H])O2)(C)CC1
InChi Code
InChI=1S/C23H28O6/c1-15-10-11-21(2)16(12-15)28-18-13-17(22(21,3)23(18)14-27-23)29-20(26)9-7-5-4-6-8-19(24)25/h4-9,12,16-18H,10-11,13-14H2,1-3H3,(H,24,25)/b5-4+,8-6+,9-7-/t16-,17-,18-,21+,22?,23?/m1/s1
InChi Key
FVRDNLIUSWSBCT-WNNZSMTESA-N
Origin
Fungus/Trichoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $1,066

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    Product Description

    Harzianum A is a trichothecene fungal metabolite originally isolated from T. harzianum.1 It is cytotoxic to HeLa, MCF-7, and HT-1080 cells (IC50s = 5.07, 10.13, and 0.65 μg/ml, respectively) and exhibits antifungal activity against C. albicans and S. cerevisiae when used at a concentration of 100 μg/ml.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corley, D.G., Miller-Wideman, M., and Durley, R.C. Isolation and structure of harzianum A: A new trichothecene from Trichoderma harzianum. J. Nat. Prod. 57(3), 422-425 (1994).

    2. Lee, H.B., Kim, Y., Jin, H.Z., et al. A new Hypocrea strain producing harzianum A cytotoxic to tumour cell lines. Lett. Appl. Microbiol. 40(6), 497-503 (2005).