A fungal metabolite
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Antibiotic PF 1052

Item No. 27743

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[2-(2,3-dimethyl-2-oxiranyl)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dimethyl-1-naphthalenyl]hydroxymethylene]-1-methyl-5-(1-methylpropyl)-2,4-pyrrolidinedione
CAS Number
147317-15-5
Molecular Formula
C26H39NO4
Formula Weight
429.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
CC1CC(C)C2C(C=CC(C3(C)C(C)O3)C2/C(O)=C4C(N(C)C(C(C)CC)C\4=O)=O)C1
InChi Code
InChI=1S/C26H39NO4/c1-8-14(3)22-24(29)21(25(30)27(22)7)23(28)20-18(26(6)16(5)31-26)10-9-17-12-13(2)11-15(4)19(17)20/h9-10,13-20,22,28H,8,11-12H2,1-7H3/b23-21+
InChi Key
NPWKEUKXVOMELT-XTQSDGFTSA-N
Origin
Fungus/Phoma sp. FKI-1840
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 µg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sasaki, T., Takagi, M., Yaguchi, M., et al. Novel antibiotic PF1052 and its manufacture with Phoma species. Jpn. Kokai Tokkyo Koho (1992).

    2. Wang, X., Robertson, A.L., Li, J., et al. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis. Model Mech. 7(1), 163-169 (2014).