A motilin receptor agonist
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EM574

Item No. 27752

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
CAS Number
110480-13-2
Synonyms
  • Idremcinal
Molecular Formula
C39H69NO12
Formula Weight
744.0
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC[C@H]([C@](O)(C)[C@H](O)[C@@H](C)C1=C(C)C[C@](O1)(C)[C@]([H])(O[C@@]2([H])[C@H](O)[C@@H](N(C(C)C)C)C[C@@H](C)O2)[C@@H](C)[C@@](O[C@]3([H])O[C@@H](C)[C@H](O)[C@](C)(OC)C3)([H])[C@H]4C)OC4=O
InChi Code
InChI=1S/C39H69NO12/c1-15-27-39(12,45)32(42)22(6)30-20(4)17-38(11,52-30)34(51-36-29(41)26(16-21(5)47-36)40(13)19(2)3)23(7)31(24(8)35(44)49-27)50-28-18-37(10,46-14)33(43)25(9)48-28/h19,21-29,31-34,36,41-43,45H,15-18H2,1-14H3/t21-,22+,23+,24-,25+,26+,27-,28+,29-,31+,32-,33+,34-,36+,37-,38-,39-/m1/s1
InChi Key
FPBKIOZMKHHNLL-CBUZSSJJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $149

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    1 mg

    $281

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    Product Description

    EM574 is a motilin receptor agonist with an IC50 value of 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay.1 It also binds to human smooth muscle homogenates in a radioligand binding assay (Kd = 7.8 nM).2 EM574 induces contraction of isolated rabbit, but not rat or guinea pig, intestine (EC50 = 5.5 nM).1 It increases antral motility and enhances gastric emptying in canine models of gastroparesis when administered intraduodenally at a dose of 0.03 mg/kg following a semi-solid meal.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, F., Sekiguchi, M., Marui, S., et al. EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit. Eur. J. Pharmacol. 322(1), 63-71 (1997).

    2. Satoh, M., Sakai, T., Fujikura, K., et al. EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum. J. Pharmacol. Exp. Ther. 271(1), 574-579 (1994).

    3. Sato, F., Marui, S., Inatomi, N., et al. EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs. Eur. J. Pharmacol. 395(2), 165-172 (2000).