A synthetic hexapeptide
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Acetyl Hexapeptide-3 (acetate)

Item No. 27756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide, acetate
Synonyms
  • Ac-EEMQRR-NH2
  • Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2
  • Acetyl Hexapeptide-8
Molecular Formula
C34H60N14O12S • XC2H4O2
Formula Weight
889.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC(CC[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)CCSC)=O)CCC(O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C34H60N14O12S.C2H4O2/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38;1-2(3)4/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42);1H3,(H,3,4)/t18-,19-,20-,21-,22-,23-;/m0./s1
InChi Key
KUOYHRQPSCEGDA-PXILYFGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $109

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    5 mg

    $382

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    Product Description

    Acetyl hexapeptide-3 is a synthetic acetylated and amidated hexapeptide consisting of amino acid residues 12-17 of synaptosomal-associated protein 25 (SNAP-25).1 It inhibits formation of the SNARE complex in vitro in a concentration-dependent manner. It also inhibits calcium-induced norepinephrine release in permeabilized chromaffin cells (IC50 = 110 μM). Acetyl hexapeptide-3 (10% in an oil-and-water emulsion) inhibits decreases in type I collagen levels and skin thickness, as well as increases in type III collagen levels, in skin in a mouse model of subacute aging induced by D-galactose (Item No. 20890) when administered topically.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blanes-Mira, C., Clemente, J., Jodas, G., et al. A synthetic hexapeptide (argireline) with antiwrinkle activity. Int. J. Cosmet. Sci. 24(5), 303-310 (2002).

    2. Wang, Y., Wang, M., Xiao, X.S., et al. The anti-wrinkle efficacy of argireline. J. Cosmet Laser Ther. 15(4), 237-241 (2013).