A biotinylated peptide fragment of histone H3
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Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Item No. 27761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-proylglycylglycyl-L-lysine biotin, trifluoroacetate salt
Synonyms
  • ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)
Molecular Formula
C127H214N44O33S • XCF3COOH
Formula Weight
2917.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(NCCCC[C@@H](C(O)=O)NC(CNC(CNC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])C)=O)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)CCCC[C@@H]6SC[C@@](N7)([H])[C@]6([H])NC7=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C127H214N44O33S.C2HF3O2/c1-66(2)98(165-97(180)62-145-95(178)60-147-117(196)99(72(8)173)167-105(184)70(6)151-115(194)90-37-26-53-169(90)120(199)71(7)152-113(192)87(63-172)163-110(189)78(29-13-18-46-129)155-107(186)80(33-22-50-141-124(133)134)154-104(183)69(5)149-103(182)68(4)150-106(185)77(28-12-17-45-128)158-119(198)100(73(9)174)166-102(181)67(3)132)118(197)157-79(30-14-19-47-130)108(187)159-82(31-15-20-48-131)121(200)171-55-27-38-91(171)116(195)162-86(57-75-58-139-65-148-75)112(191)156-81(34-23-51-142-125(135)136)109(188)161-85(56-74-41-43-76(175)44-42-74)111(190)160-83(35-24-52-143-126(137)138)122(201)170-54-25-36-89(170)114(193)146-59-94(177)144-61-96(179)153-84(123(202)203)32-16-21-49-140-93(176)40-11-10-39-92-101-88(64-205-92)164-127(204)168-101;3-2(4,5)1(6)7/h41-44,58,65-73,77-92,98-101,172-175H,10-40,45-57,59-64,128-132H2,1-9H3,(H,139,148)(H,140,176)(H,144,177)(H,145,178)(H,146,193)(H,147,196)(H,149,182)(H,150,185)(H,151,194)(H,152,192)(H,153,179)(H,154,183)(H,155,186)(H,156,191)(H,157,197)(H,158,198)(H,159,187)(H,160,190)(H,161,188)(H,162,195)(H,163,189)(H,165,180)(H,166,181)(H,167,184)(H,202,203)(H4,133,134,141)(H4,135,136,142)(H4,137,138,143)(H2,164,168,204);(H,6,7)/t67-,68-,69-,70-,71-,72+,73+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,98-,99-,100-,101-;/m0./s1
InChi Key
YNWVSXSZONJIBA-DJBOLBKISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $202

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    Product Description

    Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44) contains a lysine residue at position 23 that is subject to acetylation, an arginine at position 26 subject to methylation, and a serine at position 28 subject to phosphorylation, as well as lysine residues at positions 27 and 36 that are subject to methylation and acetylation.1 Histone H3 (21-44)-GK-biotin has been used as a substrate for the primate-specific histone methyltransferase PR domain-containing protein 7 (PRDM7) to determine substrate specificity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).

    2. Blazer, L.L., Lima-Fernandes, E., Gibson, E., et al. PR domain-containing protein 7 (PRDM7) is a histone 3 lysine 4 trimethyltransferase. The Journal of Biological Chemisty 291(26), 13509-13519 (2016).