A biotinylated peptide fragment of histone H3
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Histone H3K27Ac (21-44)-GK-biotin amide (trifluoroacetate salt)

Item No. 27764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6-acetyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-seryl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycylglycyl-L-lysine-biotin amide, trifluoroacetate salt
Synonyms
  • ATKAAR-K(Ac)-SAPSTGGVKKPHRYRPGG-K(Biotin)-NH2
Molecular Formula
C129H217N45O34S • XCF3COOH
Formula Weight
2974.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.NC([C@H](CCCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)NC(CNC(CNC([C@@H]3CCCN3C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H]4CCCN4C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC(CNC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@@H]5CCCN5C([C@@H](NC([C@H](CO)NC([C@H](CCCCNC(C)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])C)=O)=O)=O)C)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C129H217N45O34S.C2HF3O2/c1-67(2)100(168-99(185)62-148-97(183)60-150-120(202)101(72(7)177)170-116(198)89(64-176)166-119(201)92-37-26-53-172(92)123(205)71(6)154-115(197)88(63-175)165-112(194)80(31-16-20-48-142-74(9)179)157-109(191)82(33-22-50-144-126(135)136)156-107(189)70(5)152-106(188)69(4)153-108(190)79(29-12-17-45-130)160-122(204)102(73(8)178)169-105(187)68(3)133)121(203)159-81(30-13-18-46-131)110(192)161-84(32-14-19-47-132)124(206)174-55-27-38-93(174)118(200)164-87(57-76-58-141-66-151-76)114(196)158-83(34-23-51-145-127(137)138)111(193)163-86(56-75-41-43-77(180)44-42-75)113(195)162-85(35-24-52-146-128(139)140)125(207)173-54-25-36-91(173)117(199)149-59-96(182)147-61-98(184)155-78(104(134)186)28-15-21-49-143-95(181)40-11-10-39-94-103-90(65-209-94)167-129(208)171-103;3-2(4,5)1(6)7/h41-44,58,66-73,78-94,100-103,175-178,180H,10-40,45-57,59-65,130-133H2,1-9H3,(H2,134,186)(H,141,151)(H,142,179)(H,143,181)(H,147,182)(H,148,183)(H,149,199)(H,150,202)(H,152,188)(H,153,190)(H,154,197)(H,155,184)(H,156,189)(H,157,191)(H,158,196)(H,159,203)(H,160,204)(H,161,192)(H,162,195)(H,163,193)(H,164,200)(H,165,194)(H,166,201)(H,168,185)(H,169,187)(H,170,198)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H2,167,171,208);(H,6,7)/t68-,69-,70-,71-,72+,73+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-;/m0./s1
InChi Key
PSWSUKMSPCUFQY-GMBRRNLTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $253

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    Product Description

    Histone H3K27Ac (21-44)-GK-biotin amide is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence. It is acetylated at lysine 27 and biotinylated via a C-terminal GK linker. Acetylation of histone H3 at lysine 27 is associated with active gene transcription.1 H3K27 acetylation and H3K4 monomethylation are enriched near active enhancers and H3K27 acetylation and H3K4 trimethylation together mark transcription start sites of actively transcribed genes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kimura, H. Histone modifications for human epigenome analysis. J. Hum. Genet. 58(7), 439-445 (2013).