A peptide fragment of histone H3
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Histone H3 (21-44) (Phospho-Ser28) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

Item No. 27768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-O-phosphono-L-seryl-L-alanyl-L-proyl-L-seryl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycine, trifluoroacetate salt
Synonyms
  • ATKAARK-pS-APSTGGVKKPHRYRPG
  • [pSer28]-Histone H3 (21-44)
Molecular Formula
C109H186N39O33P • XCF3COOH
Formula Weight
2601.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(O)C(F)(F)F.OP(O)(OC[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(NCC(O)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])C)=O)=O)=O)C)=O)C)=O)=O)=O)=O
InChi Code
InChI=1S/C109H186N39O33P.C2HF3O2/c1-56(2)83(102(173)135-68(25-11-15-39-112)91(162)137-71(26-12-16-40-113)105(176)148-46-22-32-79(148)99(170)140-74(48-64-49-121-55-128-64)95(166)134-70(28-18-42-123-108(117)118)92(163)139-73(47-63-33-35-65(152)36-34-63)94(165)138-72(29-19-43-124-109(119)120)106(177)147-45-20-30-77(147)98(169)127-52-82(155)156)143-81(154)51-125-80(153)50-126-101(172)84(61(7)150)145-96(167)75(53-149)141-100(171)78-31-21-44-146(78)104(175)60(6)131-97(168)76(54-181-182(178,179)180)142-93(164)67(24-10-14-38-111)133-90(161)69(27-17-41-122-107(115)116)132-88(159)59(5)129-87(158)58(4)130-89(160)66(23-9-13-37-110)136-103(174)85(62(8)151)144-86(157)57(3)114;3-2(4,5)1(6)7/h33-36,49,55-62,66-79,83-85,149-152H,9-32,37-48,50-54,110-114H2,1-8H3,(H,121,128)(H,125,153)(H,126,172)(H,127,169)(H,129,158)(H,130,160)(H,131,168)(H,132,159)(H,133,161)(H,134,166)(H,135,173)(H,136,174)(H,137,162)(H,138,165)(H,139,163)(H,140,170)(H,141,171)(H,142,164)(H,143,154)(H,144,157)(H,145,167)(H,155,156)(H4,115,116,122)(H4,117,118,123)(H4,119,120,124)(H2,178,179,180);(H,6,7)/t57-,58-,59-,60-,61+,62+,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-,84-,85-;/m0./s1
InChi Key
LZEOWTMPHUXVAF-LYLFRUGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $169

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    Product Description

    Histone H3 (21-44) (phospho-Ser28) is a peptide fragment that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence. Phosphorylation of histone H3 at serine 28 is correlated with chromatin condensation during mitosis and is induced by various signaling pathways including the Aurora kinase pathway.1,2 It is present in labile nucleosomes and is associated with nucleosome disassembly in active promoters.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, J.M., Chen, H.Y., Espino, P.S., et al. Phosphorylated serine 28 of histone H3 is associated with destabilized nucleosomes in transcribed chromatin. Nucleic Acids Res. 35(19), 6640-6647 (2007).

    2. Sawicka, A., and Seiser, C. Histone H3 phosphorylation - A versatile chromatin modification for different occasions. Biochimie 94(11), 2193-2201 (2012).