An inactive metabolite of abacavir
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Parent Compound(s)
36925Abacavir 14746Abacavir (sulfate)
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Abacavir Carboxylate

Item No. 27777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic acid
CAS Number
384380-52-3
Molecular Formula
C14H16N6O2
Formula Weight
300.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
NC1=NC(N([C@H]2C=C[C@@H](C(O)=O)C2)C=N3)=C3C(NC4CC4)=N1
InChi Code
InChI=1S/C14H16N6O2/c15-14-18-11(17-8-2-3-8)10-12(19-14)20(6-16-10)9-4-1-7(5-9)13(21)22/h1,4,6-9H,2-3,5H2,(H,21,22)(H3,15,17,18,19)/t7-,9+/m1/s1
InChi Key
OCSMNHMMTKMVCP-APPZFPTMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $401

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    Product Description

    Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir (Item No. 14746).1,2 It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martin, M.A., and Kroetz, D.L. Abacavir pharmacogenetics--from initial reports to standard of care. Pharmacotherapy 33(7), 765-775 (2013).

    2. Charneira, C., Godinho, A.L.A., Oliveira, M.C., et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem. Res. Toxicol. 24(12), 2129-21241 (2011).