An activator of PKC
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Phorbol 12,13-dibutyrate

Item No. 27785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Butanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester
CAS Number
37558-16-0
Synonyms
  • PDBu
Molecular Formula
C28H40O8
Formula Weight
504.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
λmax
232 nm
SMILES
CC(C1=O)=C[C@]2([H])[C@]1(O)CC(CO)=C[C@]3([H])[C@]2(O)[C@H](C)[C@@H](OC(CCC)=O)[C@]4(OC(CCC)=O)[C@H]3C4(C)C
InChi Code
InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
InChi Key
BQJRUJTZSGYBEZ-YVQNUNKESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Phorbol 12,13-dibutyrate is a phorbol ester and an activator of PKC, including group A (α and γ) and group B (δ, ε, η) PKC isoforms.1 It promotes tumor formation to a lesser degree than phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).2 Phorbol 12,13-dibutyrate induces papilloma formation in mice with a total dose of 9.7 µmol required to produce papillomas in 50% of survivors after eight weeks.3 It also induces inflammation in 50% of mice when administered topically to the ear at a dose of 0.067 µmol/ear.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Geiges, D., Meyer, T., Marte, B., et al. Activation of protein kinase C subtypes α, γ, δ, ε, ζ, and η by tumor-promoting and nontumor-promoting agents. Biochem. Pharmacol. 53(6), 865-875 (1997).

    2. Rippmann, F. Hydrophobicity and tumor promoting activity of phorbol esters. Quant. Struct.-Act. Relat. 9(1), 1-5 (1990).

    3. Scribner, J.D., and Boutwell, R.K. Inflammation and tumor promotion: Selective protein induction in mouse skin by tumor promoters. Eur. J. Cancer 8(6), 617-621 (1972).