A derivative of lycorine with antihypertensive and neuroprotective activities
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Dihydrolycorine

Item No. 27809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
CAS Number
6271-21-2
Molecular Formula
C16H19NO4
Formula Weight
289.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 3mg/mLPBS (pH 7.2): 2.5mg/mL
λmax
242, 290 nm
SMILES
O[C@@H]1[C@@H](O)C[C@]2([H])[C@@]3([H])N(CC2)CC4=CC5=C(OCO5)C=C4[C@@]31[H]
InChi Code
InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1
InChi Key
VJILFEGOWCJNIK-MGRBZGILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $106

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    10 mg

    $175

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    25 mg

    $385

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    Product Description

    Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities.1 It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, B.Y., Du, Z.H., Zeng, F.D., et al. Hypotensive effect of dihydrolycorine. Zhongguo Yao Li Xue Bao 14(1), 45-49 (1993).

    2. Jiang, S., Yu, G., Yu, L., et al. Therapeutic effect of dihydrolycorine on focal cerebral ischemia-reperfusion injury in rats. Yunyang Yixueyuan Xuebao 28(5), 453-456 (2009).