An inactive degradation product of melphalan
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
DNA Damage and Repair

Dihydroxy Melphalan

Item No. 27857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[bis(2-hydroxyethyl)amino]-L-phenylalanine
CAS Number
72143-20-5
Molecular Formula
C13H20N2O4
Formula Weight
268.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly solubleWater: slightly soluble
SMILES
OC([C@@H](N)CC1=CC=C(N(CCO)CCO)C=C1)=O
InChi Code
InChI=1S/C13H20N2O4/c14-12(13(18)19)9-10-1-3-11(4-2-10)15(5-7-16)6-8-17/h1-4,12,16-17H,5-9,14H2,(H,18,19)/t12-/m0/s1
InChi Key
WHGUXSYETMNGJA-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $229

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    25 mg

    $392

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    Product Description

    Dihydroxy melphalan is an inactive degradation product of melphalan (Item No. 16665).1,2 It is formed by the hydrolysis of melphalan via the intermediate monohydroxy melphalan (Item No. 27856) in aqueous solutions, including cell culture medium and human plasma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bosanquet, A.G., and Bird, M.C. Degradation of melphalan in vitro: Rationale for the use of continuous exposure in chemosensitivity assays. Cancer Chemother. Pharmacol. 21(3), 211-215 (1988).

    2. Mirkou, A., Vignal, B., Cohen, S., et al. Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(27), 3089-3096 (2009).