An inhibitor of GlyT2a
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Oleoyl-D-lysine (sodium salt)

Item No. 27862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[(9Z)-1-oxo-9-octadecen-1-yl]-D-lysine, monosodium salt
Molecular Formula
C24H46N2O3 • Na
Formula Weight
433.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 0.25 mg/ml
SMILES
O=C(N[C@H](CCCCN)C(O)=O)CCCCCCC/C=C\CCCCCCCC.[Na]
InChi Code
InChI=1S/C24H46N2O3.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23(27)26-22(24(28)29)19-17-18-21-25;/h9-10,22H,2-8,11-21,25H2,1H3,(H,26,27)(H,28,29);/b10-9-;
InChi Key
OWBHGNNUDAIRSI-KVVVOXFISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    Oleoyl-D-lysine is an inhibitor of glycine transporter 2a (GlyT2a).1 It selectively inhibits GlyT2a (IC50 = 48.3 nM) over GlyT1b (IC50 = >3,000 nM) in Xenopus oocytes expressing the human transporters. Oleoyl-D-lysine (30 mg/kg, i.p.) reduces allodynia in a nerve ligation rat model of neuropathic pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mostyn, S.N., Rawling, T., Mohammadi, S., et al. Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. J. Med. Chem. 62(5), 2466-2484 (2019).