A medium-chain acyl CoA
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Octanoyl-Coenzyme A (sodium salt)

Item No. 27868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-octanoate coenzyme A, sodium salt
Synonyms
  • Octanoyl-CoA
Molecular Formula
C29H50N7O17P3S • XNa
Formula Weight
893.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Partially solublePBS (pH 7.2): 10 mg/ml
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCCCC)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
InChi Code
InChI=1S/C29H50N7O17P3S.Na/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36;/h16-18,22-24,28,39-40H,4-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44);/t18-,22-,23-,24+,28-;/m1./s1
InChi Key
APEGDHAYYMKUJF-QGYZRCADSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    Octanoyl-coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation.1,2,3 Levels of octanoyl-CoA are increased in the liver of patients with Reye’s syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD).2,3 Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lai, J.C., Liang, B.B., Jarvi, E.J., et al. Differential effects of fatty acyl coenzyme A derivatives on citrate synthase and glutamate dehydrogenase. Res. Commun. Chem. Pathol. Pharmacol. 82(3), 331-338 (1993).

    2. Corkey, B.E., Hale, D.E., Glennon, M.V., et al. Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome. J. Clin. Invest. 82(3), 782-788 (1988).

    3. Amendt, B.A., and Rhead, W.J. Catalytic defect of medium-chain acyl-coenzyme A dehydrogenase deficiency. Lack of both cofactor responsiveness and biochemical heterogeneity in eight patients. J. Clin. Invest. 76(3), 963-969 (1985).