An inducer of type I interferon production
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Cridanimod (sodium salt)

Item No. 27884

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-10(9H)-acridineacetic acid, monosodium salt
CAS Number
58880-43-6
Synonyms
  • 10-Carboxymethyl-9-Acridanone
Molecular Formula
C15H10NO3 • Na
Formula Weight
275.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
λmax
216, 255, 400 nm
SMILES
O=C1C2=CC=CC=C2N(CC([O-])=O)C3=C1C=CC=C3.[Na+]
InChi Code
InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1
InChi Key
FQMLTEAEJZVTAJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    10 mg

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    Cayman Chemical
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    Product Description

    Cridanimod is an inducer of type I interferon (IFN) production.1,2 It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.1 In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.2 Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.3 It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.4 Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cavlar, T., Deimling, T., Ablasser, A., et al. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32(10), 1440-1450 (2013).

    2. Taylor, J.L., Schoenherr, C.K., and Grossberg, S.E. High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob. Agents Chemother. 18(1), 20-26 (1980).

    3. Kramer, M.J., Cleeland, R., and Grunberg, E. Antiviral activity of 10-carboxymethyl-9-acridanone. Antimicrob. Agents Chemother. 9(2), 233-238 (1976).

    4. Surkov, K.G., Tsyrlina, E.V., Konstantinova, M.M., et al. Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer. Vopr. Onkol. 42(6), 28-32 (1996).