A triterpenoid with diverse biological activities
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Corosolic Acid

Item No. 27887

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2α,3β-dihydroxy-urs-12-en-28-oic acid
CAS Number
4547-24-4
Synonyms
  • CA
  • Glucosol
  • 2α-Hydroxyursolic Acid
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
SMILES
O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1
InChi Code
InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChi Key
HFGSQOYIOKBQOW-ZSDYHTTISA-N
Origin
Plant/Loquat leaf
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $194

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    25 mg

    $427

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    50 mg

    $702

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    Product Description

    Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties.1,2,3,4 It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively).1 Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.09 mg/ear.2 It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg.3 Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahn, K.-S., Hahm, M.S., Park, E.J., et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 64(5), 468-470 (1998).

    2. Banno, N., Akihisa, T., Tokuda, H., et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci. Biotechnol. Biochem. 68(1), 85-90 (2004).

    3. Miura, T., Ueda, N., Yamada, K., et al. Antidiabetic effects of corosolic acid in KK-Ay diabetic mice. Biol. Pharm. Bull. 29(3), 585-587 (2006).

    4. Yamaguchi, Y., Yamada, K., Yoshikawa, N., et al. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci. 79(26), 2474-2479 (2006).