A nucleoside derivative and an anticancer agent
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RX-3117

Item No. 27922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]- 2(1H)-pyrimidinone
CAS Number
865838-26-2
Synonyms
  • Fluorocyclopentenylcytosine
  • TV-1360
Molecular Formula
C10H12FN3O4
Formula Weight
257.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=C(CO)[C@@H](O)[C@@H](O)[C@@H]1N2C(N=C(N)C=C2)=O
InChi Code
InChI=1S/C10H12FN3O4/c11-6-4(3-15)8(16)9(17)7(6)14-2-1-5(12)13-10(14)18/h1-2,7-9,15-17H,3H2,(H2,12,13,18)/t7-,8-,9+/m1/s1
InChi Key
QLLGKCJUPWYJON-HLTSFMKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $382

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    10 mg

    $545

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    25 mg

    $1,089

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    Cayman Chemical
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    Product Description

    RX-3177 is a nucleoside derivative and an anticancer agent.1 It is cytotoxic to HCT116 colorectal, MDA-MB-231 breast, PANC-1 pancreatic, A549 lung, and U251 brain cancer cells (IC50s = 0.39, 0.18, 0.62, 0.34, and 0.83 µM, respectively). RX-3177 (1 and 10 µM) induces DNA damage and apoptosis in A2780 ovarian cancer cells. In vivo, RX-3177 (50-500 mg/kg) reduces mean tumor volume in HCT116, HT-29, Caki-1, MIA PaCa-2, and BxPC-3 mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balboni, B., El Hassouni, B., Honeywell, R.J., et al. RX-3117 (fluorocyclopentenyl cytosine): A novel specific antimetabolite for selective cancer treatment. Expert Opin. Investig. Drugs 28(4), 311-312 (2019).

    2. Yang, M.Y., Lee, Y.B., Ahn, C.-H., et al. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine. Anticancer Res. 34(12), 6951-6959 (2014).