A fluoroquinolone antibiotic
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Delafloxacin (meglumine)

Item No. 27935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-deoxy-1-(methylamino)-D-glucitol, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylate (1:1)
CAS Number
352458-37-8
Synonyms
  • ABT-492
  • RX-3341
Molecular Formula
C18H12ClF3N4O4 • C7H17NO5
Formula Weight
636.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.50 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230, 291 nm
SMILES
ClC1=C(N2CC(O)C2)C(F)=CC3=C1N(C4=C(F)C=C(F)C(N)=N4)C=C(C(O)=O)C3=O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
InChi Code
InChI=1S/C18H12ClF3N4O4.C7H17NO5/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
InChi Key
AHJGUEMIZPMAMR-WZTVWXICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Delafloxacin is a broad-spectrum fluoroquinolone antibiotic.1 It is active against S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes, E. faecalis, E. faecium, L. monocytogenes, E. coli, Salmonella, Shigella, C. freundii, Klebsiella, P. mirabilis, S. marcescens, S. maltophilia, H. influenzae, M. catarrhalis, N. gonorrhoeae, C. difficile, and C. perfringens in vitro (MICs = <0.004-0.25 μg/ml). Delafloxacin (3-15.5 mg/kg) reduces lung bacterial burden in mouse models of S. aureus and S. pneumoniae lung infection.2 Formulations containing delafloxacin have been used in the treatment of acute bacterial skin and skin structure infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nilius, A.M., Shen, L.L., Hensey-Rudloff, D., et al. In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrob. Agents Chemother. 47(10), 3260-3269 (2003).

    2. Lepak, A.J., and Andes, D.R. In vivo pharmacodynamic target assessment of delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a murine lung infection model. Antimicrob. Agents Chemother. 60(8), 4764-4769 (2016).