An inhibitor of MDMX
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NSC 207895

Item No. 27949

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole, 3-oxide
CAS Number
58131-57-0
Synonyms
  • NSC 179940
  • XI-006
Molecular Formula
C11H13N5O4
Formula Weight
279.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
230, 258, 348, 461 nm
SMILES
CN1CCN(C2=CC=C([N+]([O-])=O)C3=NO[N+]([O-])=C32)CC1
InChi Code
InChI=1S/C11H13N5O4/c1-13-4-6-14(7-5-13)9-3-2-8(15(17)18)10-11(9)16(19)20-12-10/h2-3H,4-7H2,1H3
InChi Key
MWFZDJLPWDCQIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $502

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    25 mg

    $1,003

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    Cayman Chemical
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    Product Description

    NSC 207895 is an inhibitor of the p53-binding protein MDMX.1 It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 µmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 µmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, H., Ma, X., Ren, S., et al. A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol. Cancer Ther. 10(1), 69-79 (2011).

    2. Pishas, K.I., Adwal, A., Neuhaus, S.J., et al. XI-006 induces potent p53-independent apoptosis in Ewing sarcoma. Sci. Rep. 5:11465, (2015).