A depsidone
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Nidulin

Item No. 27955

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,7-trichloro-3-hydroxy-8-methoxy-1,9-dimethyl-6-[(1E)-1-methyl-1-propen-1-yl]-11H-dibenzo[b,e][1,4]dioxepin-11-one
CAS Number
10089-10-8
Synonyms
  • Methylustin
Molecular Formula
C20H17Cl3O5
Formula Weight
443.7
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C(OC(C(C)=C(OC)C(Cl)=C1/C(C)=C/C)=C1O2)C3=C2C(Cl)=C(O)C(Cl)=C3C
InChi Code
InChI=1S/C20H17Cl3O5/c1-6-7(2)10-13(22)16(26-5)9(4)17-19(10)27-18-11(20(25)28-17)8(3)12(21)15(24)14(18)23/h6,24H,1-5H3/b7-6+
InChi Key
FSINAZMQWFDQSD-VOTSOKGWSA-N
Origin
Fungus/Emericella sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $224

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    5 mg

    $1,061

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    Cayman Chemical
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    Product Description

    Nidulin is a depsidone originally isolated from A. nidulans.1 It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 4 µg/ml).2 Nidulin is cytotoxic to MOLT-3 cells (IC50 = 21.2 µM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >112.7 µM). It inhibits aromatase with an IC50 value of 11.2 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dean, F.M., Roberston, A., Roberts, J.C., et al. Nidulin and “Ustin”: Two chlorine-containing metabolic products of Aspergillus nidulans. Nature 172(4372), 344 (1953).

    2. Zhang, Y., Mu, J., Feng, Y., et al. Four chlorinated depsidones from a seaweed-derived strain of Aspergillus unguis and their new biological activities. Nat. Prod. Res. 28(7), 503-506 (2014).

    3. Sureram, S., Wiyakrutta, S., Ngamrojanavanich, N., et al. Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03. Planta Med. 78(6), 582-588 (2012).