A PTP inhibitor
Related Products
Isomer(s)
19450RK-682 (calcium salt)
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TAN 1364B

Item No. 27964

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone
CAS Number
154639-24-4
Synonyms
  • RK-682 (rac-1)
Molecular Formula
C21H36O5
Formula Weight
368.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
O=C1C(C(CCCCCCCCCCCCCCC)=O)=C(O)C(CO)O1
InChi Code
InChI=1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3
InChi Key
KZTSLHQKWLYYAC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $314

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    2.5 mg

    $1,098

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    Product Description

    TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 (Item No. 19450).1 TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carneiro, V.M.T., Trivella, D.B.B., Scorsato, V., et al. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. Eur. J. Med. Chem. 97, 42-54 (2015).